Chris is known for his role of Roy in the Channel 4 comedy The IT Crowd. O'Dowd created and starred in the Sky 1 television series Moone Boy, which aired between 2012 and 2015, and for which he received a Golden Globe.
His film roles include Bridesmaids (2011), This Is 40 (2012), The Sapphires(2012), Thor: The Dark World (2013), Calvary (2014) and St. Vincent (2014). He made his Broadway debut in the play adaptation of Of Mice and Men in 2014, for which he was nominated for a Tony Award.